1963
- July 5, Southwest Missouri State College (SMS) establishes Residence Center in West Plains. The Center opens September 16 with 111 students.
1965
- North Central Association of Colleges and Secondary Schools (NCA) grants joint accreditation between SMS and Residence Center.
1973
- Southwest Missouri State University (SMSU) Residence Center receives first state funding ($50,000 for operating expenses).
1977
- Name changed to the West Plains Campus of SMSU (SMSU-WP)
- Coordinating Board of Higher Education (CBHE) authorizes awarding of Associates of Arts Degree in General Studies.
1982
- The State Board of Nursing and CBHE approve awarding of Associate of Science in Nursing.
1995
- Associate of Applied Science (AAS) degrees established.
- SMSU-WP Mountain Grove Extended Campus opens serving 60 students.
1998
- SMSU begins offering bachelor's and master's degrees on the West Plains Campus
2005
- With system name change from Southwest Missouri State University to Missouri State University campus changes to Missouri State University-West Plains (MSU-WP).